Some shunts used after epilepsy surgical procedure might threat mind shifting and persistent complications

Some shunts used after epilepsy surgical procedure might threat mind shifting and persistent complications

Surgeons who noticed persistent fluid buildup after disconnecting epileptic and wholesome mind areas ought to suppose twice earlier than putting in low-pressure nonprogrammable drainage shunts, in line with a research co-authored by Rutgers pediatric and epilepsy neurosurgeon Yasunori Nagahama that discovered persistent complications might end result from these procedures.

The research in Operative Neurosurgery adopted 70 kids who underwent a connection-severing surgical procedure referred to as useful hemispherotomy for intractable epilepsy between 1994 and 2018 to see if inserting everlasting drainage shunts after surgical procedure elevated the mind’s tendency to shift throughout the cranium after surgical procedure.

Epilepsy afflicts about 3.four million People, in line with the Facilities for Illness Management. Numerous surgical procedures might help the 1 million individuals whose seizures can’t be managed by treatment. Hemispherotomy usually eliminates seizures in juvenile sufferers whose epilepsy impacts one facet (or hemisphere) of the mind by eradicating some tissue and extreme connections between the wholesome and overactive hemispheres. Nonetheless, tissue elimination reduces native stress, inflicting the remaining mind tissue to shift towards the low-pressure zone. This shift could cause persistent complications and different issues.

The research is the primary to look at whether or not shunts, which permit extra cerebrospinal fluid to empty into the belly cavity, enhance mind shift and, if that’s the case, whether or not sure forms of shunts enhance it greater than others.

The research’s preliminary measurements of common midline mind shift have been comparable in shunted and nonshunted sufferers, however closing measurements have been 16.Three millimeters in shunted youngsters and 9.7 millimeters in nonshunted youngsters. Additional investigation by Nagahama and colleagues from the College of California, Los Angeles suggests inadequate stress in some shunt opening valves created the elevated mind shift.

Sufferers whose shunts required above-average stress to open their valves and drain fluid fared comparably to nonshunted sufferers. Sufferers whose shunts had below-average valve opening stress skilled a mean mind shift of 18.7 millimeters. Researchers additionally discovered that nonprogrammable shunt valves have been related to elevated mind shift — 18.9 millimeters — whereas programmable valves weren’t.

“The discovering that shunts as a complete enhance midline mind shift is attention-grabbing however not actionable,” mentioned Nagahama, the director of pediatric epilepsy surgical procedure at Rutgers College’s Robert Wooden Johnson Medical College. You must set up shunts when there’s persistent cerebrospinal fluid buildup.”

“The second discovering — that some forms of shunts have been related to elevated mind shift whereas others weren’t — is actually an space for additional analysis and presumably one thing for surgeons to contemplate in selecting shunts for this affected person inhabitants,” the assistant professor added .

Nagahama mentioned the research findings make intuitive sense. The mind naturally shifts from high-pressure areas to low-pressure areas till the stress equalizes. Eradicating fluid additional reduces stress in an space that is already lacking mind tissue and thus will increase mind shift. Shunts with valves that solely open at increased pressures scale back the stress differentials and scale back mind shift.

“Efforts to cut back mind shift ought to naturally deal with lowering stress variations throughout the mind cavity,” mentioned Nagahama, who focuses on epilepsy surgical procedures, together with useful hemispherotomy.


supplies supplied by Rutgers College. Initially written by Andrew Smith. Word: Content material could also be edited for fashion and size.


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